Effect of Vitamin D on Hormonal Factors in Women with Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis

Authors

  • Andriana Andriana Poltekkes Kemenkes Semarang
  • Suharyo Hadisaputro Poltekkes Kemenkes Semarang
  • Aris Santjaka Poltekkes Kemenkes Semarang

DOI:

https://doi.org/10.30994/sjik.v10i1.653

Keywords:

Polycystic Ovarian Syndrome, Randomized Controlled Trial, Vitamin D

Abstract

Women with PCOS experience hormonal disorders and vitamin D deficiency. Levels of vitamin D have a negative correlation with hormonal factors of PCOS.
Analyze the effect of vitamin D on hormonal factors in PCOS.
Search for articles through the Science Direct, PubMed, and Pro Quest databases. Inclusion criteria were publication with a randomized controlled trial design, women with PCOS, vitamin D intervention. The results measured were levels of LH, LH / FSH, TT, FT, SHBG, and DHEAS.
12 studies were analyzed. Vitamin D significantly affected LH levels (WMD, ̶ 2.16; 95% CI, ̶ 3.87 to ̶ 0.45, P = 0.01), and LH / FSH ratio (WMD, ̶ 0.28; 95% CI, ̶ 0.38 to ̶ 0.19, P <0.00001) but did not significantly affect the levels of TT, FT, SHBG, and DHEAS.
Vitamin D affects the levels of LH and LH / FSH ratio in PCOS.

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Published

2021-05-02

How to Cite

Andriana, A., Hadisaputro, S., & Santjaka, A. (2021). Effect of Vitamin D on Hormonal Factors in Women with Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis. STRADA : Jurnal Ilmiah Kesehatan, 10(1), 410–421. https://doi.org/10.30994/sjik.v10i1.653

Issue

Vol. 10 No. 1 (2021): May

Section

Articles