Hypertension Profile of Angiotensin Receptor Blocker From Matoa Leaves Extract (Pometia Pinnata J.R. Foster & G. Foster) In Angiotensin II Induced-Male Rat With Blood Volume Parameter

Authors

  • Novi Elisa STIFAR Yayasan Pharmasi Semarang
  • Fransiskus Xaverius Sulistiyanto Wibowo Sutardjo STIFAR Yayasan Pharmasi Semarang
  • Jaka Seprianto Lepangkari STIKes Ar Rum Salatiga

DOI:

https://doi.org/10.30994/sjik.v9i2.595

Keywords:

Hypertension, Pometia Pinnata, Angiotensin II, Blood Volume , Rat

Abstract

Hypertension is a problem of cardiovascular disease that occurs in many people. The leaves of matoa, which have another name, Pometia pinnata, are one of the plants used as traditional medicine for the treatment of hypertension. The active compounds of matoa leaves are flavonoids. This study aimed to observe the hypertension profile of the Angiotensin Receptor Blocker class. The test animals used in this study were 45 male Wistar rats. Each group consisted of 5 rats induced by angiotensin II, divided into groups, namely normal control, negative control, positive control, a dose of 75g/kgBW, 150g/kgBW, and 300g/kgBW, and observation were done for 14 days. The hypertension profile observed in this study was the blood volume of rats. The percentage reduction in blood volume of rats given the best matoa leaves extract was 300 mg/kgBW, extract which showed mean difference in negative control group with a significance value of <0.05

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Published

2020-11-28

How to Cite

Elisa, N., Sutardjo, F. X. S. W., & Lepangkari, J. S. (2020). Hypertension Profile of Angiotensin Receptor Blocker From Matoa Leaves Extract (Pometia Pinnata J.R. Foster & G. Foster) In Angiotensin II Induced-Male Rat With Blood Volume Parameter. STRADA : Jurnal Ilmiah Kesehatan, 9(2), 1830–1836. https://doi.org/10.30994/sjik.v9i2.595

Issue

Vol. 9 No. 2 (2020): November

Section

Articles