Betel Leaf Extract Efficacy on Wound Healing: A Systematic review
Betel leaf extract effectively accelerates wound healing. To identify the potency of betel leaf extract in the inflammatory phase, proliferation and remodeling of wound healing phases. Literature quest: PubMed, EBSCO host, Proquest, Science Direct, DOAJ and GARUDA. As many as five articles were reviewed, In acute wounds, the level of IL-1β betel leaf extract at a concentration of 3% (ρ˂ 0.002, r = 0.701) has an effect on inflammation. Diabetes mellitus ulcers, blood vessel growth and increased collagen layer thickening affect cell proliferation, increased epithelialization, more melanin, melanocyte and fibrous tissue formation (ρ<0.05), increased granulation tissue weight (ρ<0.05), hydroxyproline content increased (ρ<0.05), epidermal thickening, more lots of fibroblasts and few macrophages, and inhibiting bacterial growth (ρ<0.05). Betel leaf extract has the potential to heal wounds both acute wounds, infection wounds and diabetic ulcers.